THZ2- Shanghai Caerulum Pharma Discovery

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THZ2

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Shanghai Caerulum Pharma Discovery

Business Type:Manufacturer

Country/Region:China

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HOT Rank

8/10

Product Information

CAS:1604810-84-5
Active Ingredients:N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]benzamide
Chemical Formula:C31H28ClN7O2
Molecular Weight:566.06
Assay:min 98%
Pharmacopeia:CP
Shelf Life:2 years
Storage:Sealed
Place of Origin:China

Description

THZ2, an analog of THZ1, with the potential to treat Triple-negative breast cancer (TNBC), it is a potent and selective CDK7 inhibitor which overcomes the instability of THZ1 in vivo. IC50: CDK7= 13.9 nM; TNBC cells= 10 nM

Shanghai Caerulum Pharma Discovery is the manufacturer of APIs and intermediates of some of the latest compounds in the market. Our focus is on cancer, diabetes and other therapeutic areas.

Shanghai Caerulum Pharma Discovery (CPD) offers high quality and reliable chemical products and integrated biological services including:

1) Best offer for existing APIs and intermediates

2) Custom-synthesis APIs and intermediates

3) DMPK

4) Biological screening

5) Drug Safety Evaluation